丝氨酸/苏氨酸蛋白激酶NEK8抗体品牌 英文名称  Anti-NEK8

中文名称  丝氨酸/苏氨酸蛋白激酶NEK8抗体品牌 

别    名 JCK; NEK 8; NEK12A; NEK8; NEK8_HUMAN; Never in mitosis A-related kinase 8; NIMA-family kinase NEK8; NIMA-related kinase 12a; Nima-related protein kinase 12a; NimA-related protein kinase 8; Serine/threonine-protein kinase Nek8.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Dog, Cow

产品类型   一抗  

研究领域    细胞生物 细胞周期蛋白 激酶和磷酸酶 表观遗传学

蛋白分子量  predicted molecular weight: 75kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human NEK8

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

丝氨酸/苏氨酸蛋白激酶NEK8抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Required for renal tubular integrity.

Tissue specificity: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.Function : Required for renal tubular integrity. May regulate localcytoskeletal structure in kidney tubule epithelial cells. Mayregulate ciliary biogenesis through targeting of proteins to thecilia (By similarity).Subunit : Interacts with PKD2; may regulate PKD2 targeting to thecilium (By similarity).Subcellular Location : Cytoplasm (By similarity). Cytoplasm,cytoskeleton. Cell projection, cilium (By similarity).Note=Predominantly cytoplasmic. Localizes to the proximal region ofthe primary cilium and is not observed in dividing cells.Tissue Specificity : Highest expression in thyroid, adrenal glandand skin. Low levels in spleen, colon and uterus. Overexpressed inbreast tumors, with highest expression in infiltrating ductalcarcinomas and moderate levels in mucinous adenocarcinoma.DISEASE : Defects in NEK8 are the cause of nephronophthisis type 9(NPHP9) [MIM:613824]. NPHP9 is an autosomal recessive disorderresulting in end-stage renal disease. It is a progressivetubulo-interstitial kidney disorder histologically characterized bymodifications of the tubules with thickening of the basementmembrane, interstitial fibrosis and, in the advanced stages,medullary cysts.Similarity : Belongs to the protein kinase superfamily. NEK Ser/Thrprotein kinase family. NIMA subfamily.Contains 1 protein kinase domain.Contains 5 RCC1 repeats.Database links : UniProtKB/Swiss-Prot: Q86SG6.1

实验流程：

全、新、优、品、好四大特点：

丝氨酸/苏氨酸蛋白激酶NEK8抗体品牌 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

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技术外包服务:

★丝氨酸/苏氨酸蛋白激酶NEK8抗体品牌 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。