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脑受体蛋白1抗体说明书 英文名称  Anti-NETO1

中文名称  脑受体蛋白1抗体说明书 

别    名 BCTL1; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 1; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1; BTCL1; Neto1; NETO1_HUMAN; Neuropilin and tolloid like 1; Neuropilin and tolloid-like protein 1.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit

产品类型   一抗  

研究领域    神经生物学 细胞膜受体

蛋白分子量  predicted molecular weight: 56kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human NETO1

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

脑受体蛋白1抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 NETO1 is a 533 amino acid protein that contains one LDL-receptor class A domain and two CUB domains and is either membrane-bound or secreted. Expressed as three alternatively spliced isoforms, the first two of which are retina-specific and the third of which is found in both retina and brain tissue, NETO1 is thought to be involved in the development and maintenance of neuronal circuitry, possibly playing a role in proper brain function. Human NETO1 shares 95% amino acid identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding NETO1 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.

Function : Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.Subunit : Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains.Subcellular Location : Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Component of the postsynaptic density (PSD) of excitatory synapses. Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential).Isoform 1: Secreted (Potential).Tissue Specificity : Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.Similarity : Contains 2 CUB domains.Contains 1 LDL-receptor class A domain.

实验流程：

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