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| 产地 | 进口、国产 |
| 品牌 | 上海莼试 |
| 保存条件 | Store at -20 °C |
| 货号 | CS9878 |
| 应用范围 | WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| CAS编号 | |
| 抗体名 | Anti-NHE1/APNH1 |
| 克隆性 | |
| 靶点 | 详见说明书 |
| 适应物种 | 详见说明书 |
| 形态 | 详见说明书 |
| 宿主 | 详见说明书 |
| 亚型 | IgG |
| 标识物 | 详见说明书 |
| 浓度 | 1mg/1ml% |
| 免疫原 | KLH conjugated synthetic peptide derived from human NHE1 |
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钠氢通道蛋白抗体规格 英文名称 Anti-NHE1/APNH1
中文名称 钠氢通道蛋白抗体规格
别 名 APNH; APNH1; FLJ42224; Na Li countertransporter; Na+ H+ antiporter amiloride-sensitive; Na+ H+ antiporter; Na+ H+ exchanger 1; NHE1; OTTHUMP00000004468; SLC9A1; Sodium hydrogen exchanger 1; solute carrier family 9; Solute carrier family 9 member 1; Solute carrier family 9 sodium hydrogen exchanger isoform 1 antiporter Na+ H+ amiloride sensitive; SL9A1_HUMAN; Sodium / Hydrogen Exchanger 1.
产品属性:
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit
产品类型 一抗
研究领域 心 细胞生物 信号转导 通道蛋白 转运蛋白
蛋白分子量 predicted molecular weight: 91kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human NHE1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
钠氢通道蛋白抗体规格 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 NHE1 ( Na+/H+ Exchanger) is maintains in the cell one of environment main cell membrane protein, its main function is adjusts in the cell the pH value, makes it to maintain in the physiological scope. In the cell the pH value change, is direct or the indirect influence cell growth splits, the multiplication and the differentiation, also affects the cell the death. activeness also affects the cell the migration and the tumor cell shift. At present the main direction is: Research digestive tract tumor cell shift.
Function : Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.Subunit : Oligomer (By similarity). Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminus domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Kidney and intestine.Post-translational modifications : O-glycosylated.Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).Similarity : Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.Database links : UniProtKB/Swiss-Prot: P19634.2通道蛋白(Channel Protein)钠-氢交换蛋白(NHE: Na+/H+ Exchanger)是维持细胞内环境的主要细胞膜蛋白质之一,它的一个主要功能是调节细胞内pH值,使之保持在生理范围之内。细胞内pH值的变化,直接或间接的影响细胞的生长分裂、增殖和分化,也影响细胞的死亡。钠-氢交换蛋白质的活性还影响细胞的移动和细胞的转移。目前主要方向是:研究细胞转移。
实验流程:

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