全、新、优、品、好四大特点：

高分子量神经丝蛋白抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

高分子量神经丝蛋白抗体规格 英文名称  Anti-NF-H/Neurofilament H/Neurofilament 200/NF200

中文名称  高分子量神经丝蛋白抗体规格 

别    名 200 kDa neurofilament protein; 200 kD Neurofilament Heavy; NEFH; NEFH; NF200; NF-200; Neurofilament H; Neurofilament heavy polypeptide 200kD; Neurofilament heavy polypeptide 200kDa; Neurofilament heavy polypeptide; Neurofilament triplet H protein; Neurofilament triplet H protein; Hypophosphorylated Neurofilament H; NF H; NF-H; NFH; NFH_HUMAN; KIAA0845.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗  

研究领域    细胞生物 神经生物学 信号转导 细胞凋亡 转录调节因子

蛋白分子量  predicted molecular weight: 118kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human NF-H N-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

高分子量神经丝蛋白抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. When visualised using an electron microscope, neurofilaments appear as 10nm diameter fibres of indeterminate length that generally have fine wispy protrusions from their sides. They are particularly abundant in axons of large projection neurons. They probably function to provide structural support for neurons and their synapses and to support the large axon diameters required for rapid conduction of impulses down axons. Neurofilaments are composed of a mixture of subunits, which usually includes the three neurofilament triplet proteins neurofilament light (NFL), neurofilament medium (NFM) and neurofilament heavy (NFH). Neurofilaments may also include smaller amounts of peripherin, alpha internexin, nestin and in some cases vimentin. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable. Some studies have shown that levels of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal lobe dementia, and vascular dementia.

Function : Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.Post-translational modifications : There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.DISEASE : Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Similarity : Belongs to the intermediate filament family.Database links :Entrez Gene: 4744 HumanEntrez Gene: 380684 MouseEntrez Gene: 24587 RatOmim: 162230 HumanSwissProt: P12036 HumanSwissProt: P19246 MouseSwissProt: P16884 RatUnigene: 198760 Human神经生物学相关蛋白（Neurobiology）高分子量神经丝蛋白,简称NF-H,分子量为200kDa神经丝是中间纤维的一种重要类型又称神经微丝蛋白，特异地在神经细胞内表达，并在轴突内相互平行排列成束.　哺乳动物的神经丝由3种蛋白组成：低分子量神经丝蛋白，简称NF-L；分子量为68kDa；中分子量神经丝蛋白，简称NF-M；分子量为160kDa；高分子量神经丝蛋白，简称NF-H，分子量为200kDa；经纤丝蛋白的功能是提供弹性使神经纤维易于伸展和防止断裂。NF是神经元特异性中间丝蛋白，由三个不同分子量的亚单位构成的多聚体，以不同的比例分布于中枢、外周神经元以及中，其阳性主要于节细胞神经瘤、副节瘤、小脑或外周神经母细胞瘤、肾上腺瘤或外周嗜铬细胞瘤，有助于神经母细胞瘤和嗜铬细胞瘤的诊断与鉴别诊断。

实验流程：

正在热销的相关产品：

Mouse Lysozyme,LZM ELISA Kit 小鼠溶菌酶Multi-class antibodies规格： 48T

Anti-BTG2/TIS21/FITC 荧光素标记B细胞迁移基因2抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh Eph receptor A2+A3+A4 内皮细胞受体蛋白酪氨酸激酶A2+A3+A4抗体 规格 0.2ml

IL-1sR I (Rabbit soluble interleukin-1 receptor I ) ELISA Kit 兔子白介素1可溶性受体I 96T

MUC13 英文名称： 粘蛋白13抗体 0.2ml

ADRA2C 英文名称： α2C-AR能受体抗体 0.2ml

Anti-BTG2/TIS21/FITC 荧光素标记B细胞迁移基因2抗体IgGMulti-class antibodies规格： 0.2ml

cTn- I (Mouse cardiac troponin I ) ELISA Kit 小鼠心肌肌钙蛋白ⅠMulti-class antibodies规格： 48T

Anti-CD44v4 /FITC 荧光素标记兔抗人、大、小鼠CD44V4抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh DRIP1/C14orf28 多巴胺受体相互作用蛋白1抗体 规格 0.2ml

SAA (Rabbit Serum amyloid A) ELISA Kit 兔血清淀粉样蛋白A 96T

MMP-17 英文名称： 基质金属蛋白酶-17抗体 0.1ml

ABCG1 英文名称： 三磷酸腺苷结合盒亚家族G1抗体 0.1ml

Anti-CD44v4 /FITC 荧光素标记兔抗人、大、小鼠CD44V4抗体IgGMulti-class antibodies规格： 0.2ml

Anti-GPR14/FITC 荧光素标记G蛋白偶联受体14抗体IgGMulti-class antibodies规格： 0.2ml

Anti-P38 MAPK/RBITC 红色荧光素罗丹明(RBITC)标记原活化蛋白激酶p38抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh beta-Amyloid(35-42) β淀粉样肽/Aβ42抗体 规格 0.1ml

C-Peptide( C-PEP ) C-肽(C肽) 0.5mg

HP1 gamma 英文名称： 异染色质蛋白1-γ抗体 0.2ml

Rhesus antibody Rh Rarres3/TIG3 视黄酸受体应答蛋白3抗体 规格 0.1ml

Anti-P38 MAPK/RBITC 红色荧光素罗丹明(RBITC)标记原活化蛋白激酶p38抗体IgGMulti-class antibodies规格： 0.2ml

盐培养基基础培养基，用于细菌盐还原试验，KCN抑制试验(GB、SN标准)

GAMAgar,Modified

葡萄糖胰蛋白胨琼脂 Glucose Tryptone Agar 250 用于嗜热菌芽孢(需氧芽孢总数、平酸芽孢和厌氧芽孢)分离培养(SN标准)

MT培养基250g/瓶用于植物组织培养incubationmediaMT培养基250g/瓶用于植物组织培养

含225ml志贺氏菌増菌肉汤均质袋 10个/包 用于志贺氏菌前增菌培养

GentamycinAgar

酪蛋白钙琼脂 incubation media 酪蛋白钙琼脂

TyrosineAgarBase 500g 用于蜡样芽孢杆菌的L-酪氨酸分解试验。Tyrosine agar is used for tyrosine decompose test by B...

Cary-Blair氏运送培养基(不含琼脂)Cary-BlairTransportMedium用于运送肠道致病菌标本

黄素 5mg*5 添加于200ml HB160中制成LB2

高分子量神经丝蛋白抗体规格 营养琼脂(NA)瓶装颗粒培养基  规格：  250g  用途：  用于细菌总数测定、纯培养及保存菌种，也可用于消毒效果测定

胰蛋白胨大豆肉汤(TSB)瓶装颗粒培养基  规格：  250g  用途：  用于一般细菌的培养，药品、生物制品的无菌试验

盐胱酸增菌液(SC)瓶装颗粒培养基  规格：  250g  用途：  用于沙门氏菌选择性增菌培养

乳糖胆盐发酵培养基(麦康凯肉汤)瓶装颗粒培养基  规格：  250g  用途：  用于多管发酵法测定药品、纯净水和一次性使用卫生用品中大肠菌群、粪大肠菌群和大肠杆菌

技术外包服务:

★高分子量神经丝蛋白抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。