钠钙交换蛋白2抗体品牌 英文名称  Anti-NCX2/SLC8A2

中文名称  钠钙交换蛋白2抗体品牌 

别    名 Sodium/calcium exchanger 2; solute carrier family 8 (sodium/calcium exchanger), member 2; Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+ exchanger 2; sodium/calcium exchanger 2 precursor; Slc8a2; NAC2_HUMAN; SLC8A2.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig

产品类型   一抗  

研究领域    细胞生物 免疫学 神经生物学 信号转导 交换蛋白

蛋白分子量  predicted molecular weight: 98kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human NCX2 C-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

钠钙交换蛋白2抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.

Function : Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).Subcellular Location : Membrane; Multi-pass membrane protein.Similarity : Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.Contains 2 Calx-beta domains.Database links : UniProtKB/Swiss-Prot: Q9UPR5.2钠钙交换蛋白又称钠钙交换体，有三种同分异构体,即NCX1、NCX2和NCX3。2型Na-Ca交换蛋白-NCX2, 很多组织中都有表达，分布与胞浆及胞膜。

实验流程：

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