多聚腺苷酸结合蛋白抗体品牌 英文名称  Anti-PABP

中文名称  多聚腺苷酸结合蛋白抗体品牌 

别    名 PAB 1; PAB1; PABP 1; PABP1; PABP-1; PABPC 1; PABPC1; PABPC2; PABPL1v Poly A binding protein 1; Poly A binding protein cytoplasmic 1; Polyadenylate binding protein 1.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Pig, Horse, Rabbit

产品类型   一抗  

研究领域    免疫学 信号转导 转录调节因子

蛋白分子量  predicted molecular weight: 70kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PABP

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

多聚腺苷酸结合蛋白抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010].

Function : Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.

Subunit : Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with IGF2BP1.

Subcellular Location : Cytoplasm. Nucleus.

Post-translational modifications : Phosphorylated by MAPKAPK2.

Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine.

Similarity : Belongs to the polyadenylate-binding protein type-1 family.

Contains 1 PABC domain.

Contains 4 RRM (RNA recognition motif) domains.

Database links : NCBI Reference Sequence: NP_002559.2

UniProtKB/Swiss-Prot: P11940.2

实验流程：

全、新、优、品、好四大特点：

多聚腺苷酸结合蛋白抗体品牌 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

CK-18(Human cytokeratin 18) ELISA Kit 人细胞角蛋白18Multi-class antibodies规格： 48T

Anti-HDAC1/HD1 组蛋白去乙酰化酶1抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh Menin/Men1 Menin蛋白抗体 规格 0.2ml

PON(Human paraoxonase) ELISA Kit 人对氧磷酶 96T

RBBP5 英文名称： 视网膜母细胞瘤结合蛋白5抗体 0.2ml

C1orf64 英文名称： 1号染色体开放阅读框64抗体 0.2ml

Anti-HDAC1/HD1 组蛋白去乙酰化酶1抗体Multi-class antibodies规格： 0.2ml

GCP-2 human 人中性粒细胞趋化蛋白-2Multi-class antibodies规格： 48T

Anti-cofilin 丝切蛋白抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh Notch 2 跨膜受体蛋白Notch-2抗体 规格 0.1ml

Human macrophage inflammatory protein 2,MIP-2 ELISA Kit 人巨噬细胞炎性蛋白2 96T

TdT 英文名称： 末端脱氧核苷酸转移酶抗体 0.2ml

C6orf168 英文名称： 6号染色体开放阅读框168抗体 0.2ml

Anti-cofilin 丝切蛋白抗体Multi-class antibodies规格： 0.2ml

Anti-Neuro D/FITC 荧光素标记抗神经源分化因子抗体IgGMulti-class antibodies规格： 0.2ml

Anti-VHL/FITC 荧光素标记一种抑制因子抗体IgGMulti-class antibodies规格： 0.2ml

水通道蛋白-4抗体 Anti-AQP4 0.1ml

Goat Anti-human IgM/AP 碱性磷酸酶(AP)标记的羊抗人IgM 0.1ml

GMCL1L 英文名称： 细胞样蛋白1样蛋白抗体 0.2ml

Rhesus antibody Rh PRKCQ/PKC theta 蛋白激酶C theta抗体 规格 0.1ml

Anti-VHL/FITC 荧光素标记一种抑制因子抗体IgGMulti-class antibodies规格： 0.2ml

大鼠磷脂酶A2(PL-A2)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人肾胺酶(RNLS/MAO-C)免疫试剂盒 Human Renalase/ Monoamine Oxidase-C,RNLS/MAO-C ELISA Kit

MousegranzymesA,Gzms-AELISAKit小鼠颗粒酶A(Gzms-A)ELISA试剂盒规格：96T/48T

人神经营养因子3(-3)ELISA试剂盒人神经营养因子3(-3)ELISA试剂盒规格：96T/48T

Humanmaturationpromotingfactor,MPFELISA试剂盒人成熟促进因子(MPF)ELISA试剂盒规格：96T/48T

Humanplaceagrowthfactor，PLGFELISAKit人胎盘生长因子(PLGF)ELISA试剂盒规格：96T/48T

大鼠补体3a(C3a)ELISA试剂盒 ，英文名： C3a ELISA Kit

Rat superoxide dismase (SOD) ELISA Kit 大鼠超氧化物歧化酶(SOD)ELISA试剂盒

RatcomplemefactorH,CFHELISAKit 大鼠补体因子H(CFH)ELISA试剂盒 96T/48T 进口分装

CLIAKitforCoxV-IgG(HumanCoxsackievirusIgG)ELISAKit人柯萨奇病毒IgG规格：48T/96T

细胞乙醇比色法定量检测试剂盒20次

RatComplemefragme5a,C5aELISAKit大鼠补体片断5a(C5a)ELISA试剂盒规格：96T/48T

多聚腺苷酸结合蛋白抗体品牌 大鼠蛋白激酶Cθ(PKCθ)ELISA试剂盒 ，英文名： PKCθ ELISA Kit

N terminal brain naiuretic peptide (-proBNP) ELISA Kit 人N端前脑素(-proBNP)ELISA试剂盒

Ratsolubleierleukin-1receptorⅡ,IL-1sRⅡELISAkit 大鼠白介素1可溶性受体Ⅱ(IL-1sRⅡ)ELISA试剂盒 96T/48T 进口分装

CLIAKitforCyclin-D1ELISAKit大鼠细胞周期素D1规格：48T/96T

细胞色素P450亚酶CYP2E(AH)活性荧光定量检测试剂盒20次

Ratferritin,FEELISAKit大鼠铁蛋白(FE)ELISA试剂盒规格：96T/48T

技术外包服务:

★多聚腺苷酸结合蛋白抗体品牌 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。