激活蛋白抗体费用 英文名称  Anti-PDZK3

中文名称  激活蛋白抗体费用 

别    名 Activated in prostate cancer protein; AIPC; KIAA0300; Likely ortholog of rat plakophilin related armadillo repeat protein interacting PDZ protein antibody PAPIN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain containing protein 3; PDZD2; PDZK 2; PDZK2; PDZK-2; PDZK 3; PDZK3; PDZK-3; PIN1; Plakophilin related armadillo repeat protein interacting PDZ protein like; Rat plakophilin related armadillo repeat protein interacting PDZ protein like; PDZD2_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Horse

产品类型   一抗  

研究领域     细胞生物 免疫学 信号转导

蛋白分子量  predicted molecular weight: 310kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PDZK3

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

激活蛋白抗体费用 产品应用   ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. PDZK3 contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, the PDZK3 gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.

Subunit : Interacts with SCN10A, CTNND2 and PKP4 (By similarity).

Subcellular Location : Cytoplasmic, Endoplasmic reticulum, Nuclear and Secreted

Tissue Specificity : Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.

Similarity : Contains 6 PDZ (DHR) domains.

Database links :

Entrez Gene: 23037 Human

Entrez Gene: 68070 Mouse

Entrez Gene: 65034 Rat

Omim: 610697 Human

SwissProt: O15018 Human

SwissProt: Q9QZR8 Rat

实验流程：

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