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| 产地 | 进口、国产 |
| 品牌 | 上海莼试 |
| 保存条件 | Store at -20 °C |
| 货号 | CS10319 |
| 应用范围 | ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| CAS编号 | |
| 抗体名 | Anti-PLSCR3 |
| 克隆性 | |
| 靶点 | 详见说明书 |
| 适应物种 | 详见说明书 |
| 形态 | 详见说明书 |
| 宿主 | 详见说明书 |
| 亚型 | IgG |
| 标识物 | 详见说明书 |
| 浓度 | 1mg/1ml% |
| 免疫原 | KLH conjugated synthetic peptide derived from human PLSCR3 |
磷脂爬行酶3抗体品牌 英文名称 Anti-PLSCR3
中文名称 磷脂爬行酶3抗体品牌
别 名 Ca(2+)-dependent phospholipid scramblase 3; Phospholipid scramblase 3; PL scramblase 3; PLS3; PLS3_HUMAN.
产品属性:
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 心 细胞生物 信号转导 激酶和磷酸酶
蛋白分子量 predicted molecular weight: 32kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human PLSCR3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
磷脂爬行酶3抗体品牌 产品应用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 PLSCR3 (phospholipid scramblase 3) may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.
Function : May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.
Subunit : Interacts with PDCD6 in a calcium-dependent manner.
Subcellular Location : Mitochondrion membrane; Single-pass type II membrane protein.
Post-translational modifications : Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity.
Similarity : Belongs to the phospholipid scramblase family.
Database links : UniProtKB/Swiss-Prot: Q9NRY6.2
实验流程:

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