中文名称  多核苷酸磷酸化酶蛋白抗体规格 

英文名称  Anti-PNPT1

别    名 OLD35; PNPASE; PNPase 1; Polynucleotide phosphorylase like protein; Polyribonucleotide nucleotidyltransferase 1, mitochondrial; PNPT1_HUMAN.

产品属性：

多核苷酸磷酸化酶蛋白抗体规格 浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Cow, Horse, Sheep

产品类型   一抗  

研究领域    细胞生物 细胞凋亡 表观遗传学

蛋白分子量  predicted molecular weight: 81kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PNPT1

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

多核苷酸磷酸化酶蛋白抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PNPT1 is a subunit of the exosome complex, which is involved in 3-prime-to-5-prime exoribonuclease activity for RNA processing and degradation. It contains one KH domain and one S1 motif domain.

Function : RNA-binding protein implicated in numerous RNA metabolic processes. Hydrolyzes single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.

Subunit : Homotrimer; in free form. Homooligomer. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with TCL1A; the interaction has no effect on PNPT1 exonuclease activity.

Subcellular Location : Cytoplasm. Mitochondrion. Mitochondrion intermembrane space; Peripheral membrane protein.

Contains 1 KH domain.

Contains 1 S1 motif domain.

Database links : UniProtKB/Swiss-Prot: Q8TCS8.2

实验流程：

全、新、优、品、好四大特点：

多核苷酸磷酸化酶蛋白抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★多核苷酸磷酸化酶蛋白抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

IL-11(Human Interleukin 11) ELISA KIT 人白介素11Multi-class antibodies规格： 48T

Anti-GRK1 G蛋白偶合受体激酶1抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh MOG 髓鞘少树突胶质细胞糖蛋白抗体 规格 0.1ml

GTE-AGE(Human Glomerular tissue extract-advanced glycosylation end products) ELISA Kit 人肾小球组织糖基化终末产物 96T

Rho GTPase activating protein 29 英文名称： Rho GTP酶激活蛋白29抗体 0.2ml

Phospho-c-Kit(Tyr703) 英文名称： 磷酸化原癌基因c-kit抗体 0.1ml

Anti-GRK1 G蛋白偶合受体激酶1抗体Multi-class antibodies规格： 0.2ml

ANG 人紧张素Multi-class antibodies规格： 48T

Anti-CK16 细胞角蛋白16抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh NSDHL 类固醇脱氢酶样蛋白NSDHL抗体 规格 0.2ml

PVDF(Polyvinylidene Fluoride Membrane) PVDF膜/二氟化树脂膜(膜孔径:0.45um) 15X20cm

TRIM41 英文名称： 环指蛋白调节蛋白激酶C蛋白抗体 0.2ml

C9orf135 英文名称： 9号染色体开放阅读框135抗体 0.2ml

Anti-CK16 细胞角蛋白16抗体Multi-class antibodies规格： 0.1ml

Anti-Phospho-HER2(Tyr1221/1222)/FITC 荧光素标记磷酸化HER2受体抗体IgGMulti-class antibodies规格： 0.2ml

Anti-P-fscn1/FITC 荧光素标记磷酸化纤维束蛋白同源物1/肌动蛋白集束蛋白/圆线虫 抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh AXUD1 转化生长因子β诱导蛋白3抗体(半胱氨酸和丝氨酸富含核蛋白1) 规格 0.2ml

rDen-2(rh-Dengue Virus) 重组人病毒2型诊断抗原 100ug

Gli3 英文名称： 转录因子Gli3抗体 0.2ml

Rhesus antibody Rh Rabbit Anti-pig IgG 兔抗猪IgG 规格 1mg

Anti-P-fscn1/FITC 荧光素标记磷酸化纤维束蛋白同源物1/肌动蛋白集束蛋白/圆线虫 抗体IgGMulti-class antibodies规格： 0.2ml

大鼠抗中性粒细胞核周抗体(pANCA)ELISA试剂盒 ，英文名： pANCA ELISA Kit

人白介素9(IL-9)ELISA检测试剂盒HumanIerleukin9,IL-9ELISAKIT 96T/48T

Mouse Ficolin-2(FCN2)免疫试剂盒 Mouse FCN2 ELISA Kit

CLIAKitforObestatin(HumanGhrelin/GHRP)ELISAKit人抑制素ELISA试剂盒规格：48T/96T

体外非细胞系统细胞色素P450亚酶(CYP-ECOD)总活性荧光定量检测试剂盒20次

ELISAKitAβ1-40人β淀粉样蛋白1-40规格：48T/96T

大鼠白介素4(IL4)ELISA试剂盒 ，英文名： IL4 ELISA Kit

The human ierferon beta (IFN- beta /IFNB) ELISA Kit 人β干扰素(IFN-β/IFNB)ELISA试剂盒

PlaVitaminB12,VB12ELISAKit 植物维生素B12(VB12)ELISA试剂盒 96T/48T 进口分装

CMVIgM巨细胞病毒IgM(捕获法二步法)

细胞游离脂肪酸酶连续循环比色法定量检测试剂盒10次

Ratcardioophln1,CT-1ELISAKit大鼠心肌营养素1(CT-1)ELISA试剂盒规格：96T/48T

多核苷酸磷酸化酶蛋白抗体规格 大鼠雌酮(E1)ELISA试剂盒 ，英文名： E1 ELISA Kit

Mouse collagen type II (Col II) ELISA Kit 小鼠Ⅱ型胶原(Col Ⅱ)ELISA试剂盒

ELISA 小鼠细胞毒性T淋巴细胞相关抗原4 (mouse CTLA-4) 48T/96T 进口分装

CLIAKitforLHELISAKit鱼促黄体激素规格：48T/96T

通用型HHV6-B(HUMANHERPESVIRUS6-B)病毒定量PCR扩增检测试剂盒20次

ELISAKitGFAP猴子神经胶质纤维酸性蛋白规格：48T/96T