技术外包服务:

★枯草溶菌素转化酶1抑制剂抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

实验流程：

枯草溶菌素转化酶1抑制剂抗体规格 英文名称  Anti-PROSAAS

中文名称  枯草溶菌素转化酶1抑制剂抗体规格 

别    名 b-LEN; b-PEN-LEN; b-SAAS; Big LEN; granin like neuroendocrine peptide; l-LEN; l-SAAS; N-proSAAS; PCSK1_RAT; Pcsk1n; pro-SAAS; Proprotein convertase 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; PROSAAS; SAAS; SAAS CT(1-49); SAAS CT(25-40).

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Mouse, Rat

产品类型   一抗  

研究领域    细胞生物 神经生物学 信号转导 生长因子和激素 病 泛素 Alzheimer's

蛋白分子量  predicted molecular weight: 24kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from rat PROSAAS (34-130aa)

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

枯草溶菌素转化酶1抑制剂抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PCSK1N is a 260 amino acid protein that is both secreted and localized to the trans-Golgi network. Expressed in pancreas and brain, PCSK1N is thought to play a role in the control of the neuroendocrine secretory pathway and may also be involved in PCSK1 inhibition. The gene encoding PCSK1N maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination, as an X and a Y chromosome lead to normal male development, while two copies of an X chromosome lead to normal female development. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.

Function : May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.

Subunit : Interacts via the C-terminal inhibitory domain with PCSK1 65 kDa form.

Subcellular Location : Secreted. Golgi apparatus > trans-Golgi network. A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1.

Post-translational modifications : Proteolytically cleaved in the Golgi. Big SAAS, Little SAAS, PEN and Big LEN are the major processed peptides in proSAAS-overexpressing PC-12 phaeochromocytoma cells (lacking PCSK1 and PCSK2 endopeptidases). Peptides corresponding to PEN and a proSAAS aa 40-59 have been detected in wild-type PC-12 cells.

Database links : UniProtKB/Swiss-Prot: Q9QXU9.1

全、新、优、品、好四大特点：

枯草溶菌素转化酶1抑制剂抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

PDGFsR- Alpha(Human Platelet-Derived Growth Factor Soluble Receptor Alpha) ELISA kit 人血血小板衍生生长因子可溶性受体αMulti-class antibodies规格： 48T

Anti-E1 glycoprotein 病毒糖蛋白抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh Mouse anti-Goat IgG ascites 小鼠抗羊IgG腹水 规格 1ml

VPI(Human vasopeptidase inhibitors) ELISA Kit 人活性肽酶抑制剂 96T

RNASE4 英文名称： 生成素核糖核酸酶4抗体(肌性侧索硬化症蛋白) 0.1ml

CREG2 英文名称： E1A激活基因刺激蛋白2抗体 0.2ml

Anti-E1 glycoprotein 病毒糖蛋白抗体Multi-class antibodies规格： 0.2ml

Beta Manase(Mouse Beta mannosidase) ELISA Kit 小鼠β甘露糖苷酶Multi-class antibodies规格： 48T

Anti-CHK2/Cds1 /FITC 荧光素标记抗细胞周期检测点激酶2抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh Dog IgM/Gold 胶体金标记的兔抗犬IgM抗体 规格 0.5ml

Insulin Protein/RBITC 罗丹明标记猪蛋白 0.5mg

LRIG2 英文名称： LRIG2抗体 0.2ml

氟喹诺酮类快速检测卡 50T/盒 蜂蜜、奶、奶粉

Anti-CHK2/Cds1 /FITC 荧光素标记抗细胞周期检测点激酶2抗体IgGMulti-class antibodies规格： 0.2ml

Anti-HAS/FITC 荧光素标记兔抗人血清白蛋白抗体IgGMulti-class antibodies规格： 0.2ml

Anti-TSLP/FITC 荧光素标记淋巴细胞生成素-1抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh 5-HTT 5-羟色胺转运蛋白抗体 规格 0.1ml

Mouse Anti-Bov IgG/Cy5 Cy5标记的小鼠抗IgG 0.1ml

GilZ 英文名称： 糖皮质激素诱导亮酸拉链蛋白抗体 0.2ml

Rhesus antibody Rh PTP1B 蛋白酪氨酸磷酸酶-1B 规格 0.1ml

Anti-TSLP/FITC 荧光素标记淋巴细胞生成素-1抗体IgGMulti-class antibodies规格： 0.2ml

大鼠抗抗体(AsAb)ELISA试剂盒 ，英文名： AsAb ELISA Kit

人白介素12(IL-12/P40)ELISA检测试剂盒HumanIerleukin12,IL-12/P40ELISAKIT 96T/48T

禽病毒(AIBV)核酸检测试剂盒(PCR-荧光探针法) 48T

CLIAKitforNP9HumanNandrolonePhenylpropionate)ELISAKit人苯诺龙/苯去甲睾同规格：48T/96T

体外非细胞系统细胞色素P450亚酶CYP2C(AMD)活性荧光定量检测试剂盒20次

ELISAKitACTN-3人α-辅肌动蛋白3规格：48T/96T

大鼠白介素21(IL-21)ELISA试剂盒 96T/48T 试剂盒 组装/原装

人硫酸皮肤素-硫酸软骨素PG(DSCSPG)免疫试剂盒 Human dermatan sulfate chondoitin sulfate PG,DSCSPG ELISA Kit

Plagrowthhormone,GHELISAKit植物生长激素(GH)ELISA试剂盒规格：96T/48T

石蜡切片组织P38蛋白表达NBT显色光学显微镜检测试剂盒10/20次

Humanpyruvatedehydrogenase-E1,PDHE1ELISA试剂盒人同酸脱氢酶E1(PDHE1)ELISA试剂盒规格：96T/48T

HumanichinellaaibodyELISAKit人旋毛虫抗体(ichinellaAb)ELISA试剂盒规格：96T/48T

枯草溶菌素转化酶1抑制剂抗体规格 大鼠成纤维细胞生长因子10(FGF-10)ELISA试剂盒 ，英文名： FGF-10 ELISA Kit

CXC chemokine receptor 3 (CXCR3) ELISA Kit 小鼠CXC趋化因子受体3(CXCR3)ELISA试剂盒

ELISA 小鼠血清总补体(mouse CH50) 48T/96T 进口分装

CLIAKitforLEPELISAkit大鼠瘦素规格：48T/96T

通用型HSV1(HERPESSIMPLX1)病毒定性检测试剂盒20次

ELISAKitapo-B100猴载脂蛋白B100规格：48T/96T