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★植烷酰辅酶A羟化酶2相互作用蛋白抗体说明书 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

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植烷酰辅酶A羟化酶2相互作用蛋白抗体说明书 英文名称  Anti-PHYHIP

中文名称  植烷酰辅酶A羟化酶2相互作用蛋白抗体说明书 

别    名 DYRK1A interacting protein 3; DYRK1AP3; PAHX AP1; PAHXAP1; phytanoyl CoA 2 hydroxylase interacting protein; phytanoyl CoA alpha hydroxylase associated protein; Phytanoyl CoA hydroxylase associated protein 1; Phytanoyl CoA hydroxylase interacting protein; Similar to a putative C.elegans gene encoded in cosmid M01B2; PHYIP_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型   一抗  

研究领域     心 神经生物学 结合蛋白

蛋白分子量  predicted molecular weight: 38kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PHYHIP

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

植烷酰辅酶A羟化酶2相互作用蛋白抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain, with weak expression in ovary, small intestine and ovary. In transgenic mice, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia. PHYHIP interacts with the Refsum disease gene product, PAHX, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, which is characterized by cerebellar degeneration, neurologic damage and peripheral neuropathies. PHYHIP also interacts with Dyrk1A, a protein that that is overexpressed in brain of Down-syndrome patients, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome. Significantly, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, breast and several other types of cancers.

Function : PHYHIP interacts with PHYH, suggesting a role in the development of the central nervous system. It may be involved in the development of neurological abnormalities observed in Down syndrome patients.

Subunit : Interacts with PHYH and BAI1.

Subcellular Location : Protein binding

Similarity : Belongs to the PHYHIP family.

Contains 1 fibronectin type-III domain.

Database links : UniProtKB/Swiss-Prot: Q92561.1

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植烷酰辅酶A羟化酶2相互作用蛋白抗体说明书 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

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