中文名称  丝氨酸/苏氨酸蛋白磷酸酶4C抗体规格 

英文名称  Anti-PPP4C

别    名 PP X; PP4C; Protein phosphatase X; PP-X; PP4; PP4C; PP4C_HUMAN; PPH3; PPP4; ppp4c; PPX; protein phosphatase 4 (formerly X), catalytic subunit; Protein phosphatase 4 catalytic subunit; Protein phosphatase X; protein phosphatase X, catalytic subunit; Serine/threonine protein phosphatase 4 catalytic subunit; Serine/threonine-protein phosphatase 4 catalytic subunit.

产品属性：

丝氨酸/苏氨酸蛋白磷酸酶4C抗体规格 浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Cow, Rabbit

产品类型   一抗  

研究领域    细胞生物 免疫学 信号转导 激酶和磷酸酶

蛋白分子量  predicted molecular weight: 35kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PPP4C

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

丝氨酸/苏氨酸蛋白磷酸酶4C抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Function : Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Subunit : Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.

Subcellular Location : Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.

Database links : UniProtKB/Swiss-Prot: P60510.1

实验流程：

全、新、优、品、好四大特点：

丝氨酸/苏氨酸蛋白磷酸酶4C抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★丝氨酸/苏氨酸蛋白磷酸酶4C抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

Human SS-B/La Antibody ELISA Kit 人抗SS-B/La抗体Multi-class antibodies规格： 48T

Anti-Integrin alpha 1/CD49a 整合素α1抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh Lipin 1 磷脂酸磷酸酯酶LPIN1抗体 规格 0.2ml

HSV-Ag2(Human Herpes simplex virus 2) ELISA Kit 人单纯病毒抗原2 96T

RNF135 英文名称： 环指蛋白135抗体 0.2ml

MUC1 英文名称： 粘蛋白-1/上皮膜抗原抗体 0.1ml

Anti-Integrin alpha 1/CD49a 整合素α1抗体Multi-class antibodies规格： 0.1ml

AlphaNAG(Mouse AlphaN-acetylglucosaminidase) ELISA Kit 小鼠αN已酰氨基葡糖苷酶Multi-class antibodies规格： 48T

Anti-C-erbB-4/HER4/erbB-4 /FITC 荧光素标记c-erbB-4癌基因抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh DOM3Z DOM3Z蛋白抗体 规格 0.2ml

PCDH1( Human protocadherin 1,PCDH1 )ELISA Kit 人原钙黏素1 96T

Laminin Beta 2 英文名称： 层粘连蛋白β2抗体 0.2ml

AMHR2 英文名称： 缪勒激素2型受体抗体 0.1ml

Anti-C-erbB-4/HER4/erbB-4 /FITC 荧光素标记c-erbB-4癌基因抗体IgGMulti-class antibodies规格： 0.2ml

Anti-GRM2/FITC 荧光素标记代谢型谷氨酸受体2IgGMulti-class antibodies规格： 0.2ml

Anti-phospho-P53 (Ser6)/FITC 荧光素标记磷酸化抑制基因P53抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh Bestrophin 2 卵黄状黄斑病蛋白2抗体 规格 0.2ml

CD19(B-lymphocyte antigen CD19) CD19 0.5mg

GGT7 light chain 英文名称： γ-谷酰转肽酶7轻链抗体 0.2ml

Rhesus antibody Rh RAMP/CDT2 维调节核基质相关蛋白 规格 0.2ml

Anti-phospho-P53 (Ser6)/FITC 荧光素标记磷酸化抑制基因P53抗体IgGMulti-class antibodies规格： 0.2ml

大鼠巨噬细胞移动因子(MIF)ELISA试剂盒 ，英文名： MIF ELISA Kit

人白介素2可溶性受体α链(IL-2sRα/CD25)ELISA检测试剂盒Humansolubleierleukin-2receptor,IL-2sRαELISAkit 96T/48T

病毒A亞型(FMDV-A)核酸检测试剂盒(PCR-荧光探针法) 48T

CLIAKitforNN-T4(HumanNeonatalThyroxine)ELISAKit人新生甲状腺素规格：48T/96T

体外非细胞系统细胞色素P450亚酶CYP3A4(BFCD)活性荧光定量检测试剂盒20次

ELISAKitα1-MG人α1微球蛋白规格：48T/96T

大鼠白介素1可溶性受体Ⅱ(IL-1sRⅡ)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人硫酸角质素(KS)免疫试剂盒 Human keratan sulfate,KS ELISA Kit

Plaphosphatidicacid,PAELISAKit植物凝脂酸(PA)ELISA试剂盒规格：96T/48T

石蜡切片组织PARP蛋白表达NBT显色光学显微镜检测试剂盒10/20次

HumaeceptorⅠfoheFcregionofimmunoglobulinA,FcαRⅠELISA试剂盒人免疫球蛋白AFc段受体Ⅰ(FcαRⅠ/CD89)ELISA试剂盒规格：96T/48T

HumanoponinⅠ，Tn-ⅠELISAKit人肌钙蛋白Ⅰ(Tn-Ⅰ)ELISA试剂盒规格：96T/48T

丝氨酸/苏氨酸蛋白磷酸酶4C抗体规格 大鼠叉头框蛋白M1(FOXM1)ELISA试剂盒 ，英文名： FOXM1 ELISA Kit

Rat compleme fragme 5A (C5a) ELISA Kit 大鼠补体片断5a(C5a)ELISA试剂盒

RatmajorhistocompatibilitycomplexⅢ,MHCⅢ/AgBⅢ/H-1ⅢELISAKit 大鼠主要组织相容性复合体Ⅲ类(MHCⅢ/AgBⅢ/H-1Ⅲ)ELISA试剂盒 96T/48T 进口分装

CLIAKitforCpG-ODN(HumanCpGoligodeoxynucleotide)ELISAKit人未甲基化寡聚脱氧核苷酸规格：48T/96T

细胞样品细胞色素C氧化酶表达荧光定量检测试剂盒10/50次

Ratcross-linkedC-telopeptidesofTypeⅠcollagen,CⅠCPELISAKit大鼠Ⅰ型前胶原C末端肽(CⅠCP)ELISA试剂盒规格：96T/48T