Ⅱ型胶原α1 N端前体肽抗体费用 英文名称  Anti-procollagen type IIA

中文名称  Ⅱ型胶原α1 N端前体肽抗体费用 

别    名 Collagen II N-terminal propeptide; Collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1(II); type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; COL11A3; Collagen alpha 1(II) chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC; Collagen alpha-1(II) chain; Alpha-1 type II collagen; CO2A1_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Danio rerio

产品类型   一抗  

研究领域    神经生物学 信号转导 细胞粘附分子 细胞骨架

蛋白分子量  predicted molecular weight: 17/163kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Collagen II alpha 1 N-terminal propeptide

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

Ⅱ型胶原α1 N端前体肽抗体费用 产品应用   ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Collagen type II is the most abundant protein of cartilage matrix. Two isoforms exist and collagen type IIA is involved in early development of cartilage in embryos. The collagen is produced from type II procollagen when two teloterminal propeptides are digested from the precursor and released into the circulation. Procollagen type II N-terminal propeptide is considered a marker of cartilage synthesis and the normal concentration in serum is approximately 30ng/mL.

Function : Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Subunit : Homotrimers of alpha 1(II) chains.

Subcellular Location : Secreted, extracellular space, extracellular matrix.

Post-translational modifications : Probably 3-hydroxylated on prolines by LEPREL1 (By similarity). Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.

The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX) chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL2.

DISEASE : Defects in COL2A1 are the cause of spondyloepiphyseal dysplasia congenital type (SEDC) [MIM:183900]. This disorder is characterized by disproportionate short stature and pleiotropic involvement of the skeletal and ocular systems.

Defects in COL2A1 are the cause of spondyloepimetaphyseal dysplasia Strudwick type (SEMD-STR) [MIM:184250]. A bone disease characterized by disproportionate short stature from birth, with a very short trunk and shortened limbs, and skeletal abnormalities including lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses. A distinctive radiographic feature is irregular sclerotic changes, described as dappled in the metaphyses of the long bones.

Defects in COL2A1 are the cause of achondrogenesis type 2 (ACG2) [MIM:200610]; also known as achondrogenesis-hypochondrogenesis type II. ACG2 is a disease characterized by the absence of ossification in the vertebral column, sacrum and pubic bones.

Defects in COL2A1 are the cause of Legg-Calve-Perthes disease (LCPD) [MIM:150600]; also known as Legg-Perthes disease or Perthes disease. LCPD is characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

Defects in COL2A1 are the cause of Kniest dysplasia (KD) [MIM:156550]; also known as Kniest syndrome or metatropic dwarfism type II. KD is a moderately severe chondrodysplasia phenotype that results from mutations in the COL2A1 gene. Characteristics of the disorder include a short trunk and extremities, mid-face hypoplasia, cleft palate, myopia, retinal detachment, and hearing loss.

Defects in COL2A1 are a cause of primary avascular necrosis of femoral head (ANFH) [MIM:608805]; also known as ischemic necrosis of the femoral head or osteonecrosis of the femoral head. ANFH causes disability that often requires surgical intervention. Most cases are sporadic, but families in which there is an autosomal dominant inheritance of the disease have been identified. It has been estimated that 300,000 to 600,000 people in the United States have ANFH. Approximately 15,000 new cases of this common and disabling disorder are reported annually. The age at the onset is earlier than that for osteoarthritis. The diagnosis is typically made when patients are between the ages of 30 and 60 years. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability. Moreover, nearly 10 percent of the 500,000 total-hip arthroplasties performed each year in the United States involve patients with ANFH. As a result, this disease creates a substantial socioeconomic cost as well as a burden for patients and their families.

Defects in COL2A1 are the cause of osteoarthritis with mild chondrodysplasia (OACD) [MIM:604864]. Osteoarthritis is a common disease that produces joint pain and stiffness together with radiologic evidence of progressive degeneration of joint cartilage. Some forms of osteoarthritis are secondary to events such as trauma, infections, metabolic disorders, or congenital or heritable conditions that deform the epiphyses or related structures. In most patients, however, there is no readily identifiable cause of osteoarthritis. Inheritance in a Mendelian dominant manner has been demonstrated in some families with primary generalized osteoarthritis. Reports demonstrate coinheritance of primary generalized osteoarthritis with specific alleles of the gene COL2A1, the precursor of the major protein of cartilage.

Defects in COL2A1 are the cause of platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T) [MIM:151210]. Platyspondylic lethal skeletal dysplasias (PLSDs) are a heterogeneous group of chondrodysplasias characterized by severe platyspondyly and limb shortening. PLSD-T is characterized by varying platyspondyly, short ribs with anterior cupping, hypoplasia of the lower ilia with broad ischial and pubic bones, and shortening of the tubular bones with splayed and cupped metaphyses. Histology of the growth plate typically shows focal hypercellularity with slightly enlarged chondrocytes in the resting cartilage and relatively well-preserved columnar formation and ossification at the chondro-osseous junction. PLSD-T is generally a perinatally lethal disease, but a few long-term survivors have been reported.

Defects in COL2A1 are the cause of multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD) [MIM:132450]. Multiple epiphyseal dysplasia is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDMMD is an autosomal dominant disorder characterized by epiphyseal dysplasia associated with progressive myopia, retinal thinning, crenated cataracts, conductive deafness.

Defects in COL2A1 are the cause of spondyloperipheral dysplasia (SPD) [MIM:271700]. SPD patients manifest short stature, midface hypoplasia, sensorineural hearing loss, spondyloepiphyseal dysplasia, platyspondyly and brachydactyly.

Similarity : Belongs to the fibrillar collagen family.

Contains 1 fibrillar collagen NC1 domain.

Contains 1 VWFC domain.

Database links : UniProtKB/Swiss-Prot: P02458.3

实验流程：

全、新、优、品、好四大特点：

Ⅱ型胶原α1 N端前体肽抗体费用 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

PDGF-BB(Human Platelet-Derived Growth Factor-BB) ELISA kit 人血小板衍生生长因子BBMulti-class antibodies规格： 48T

Anti-Gastrin 胃泌素/蛙皮素抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh Mouse Anti-human IgG(3D3)/Cy5.5 Cy5.5标记的鼠抗人IgG单克隆抗体 规格 0.1ml

Human similar to RIKEN cDNA 2610307008 gene ELISA Kit 人类似RIKEN cDNA 2610307008 基因 96T

RNF150 英文名称： 环指蛋白150抗体 0.2ml

Cdc23 英文名称： 细胞分裂周期蛋白23抗体 0.2ml

Anti-Gastrin 胃泌素/蛙皮素抗体Multi-class antibodies规格： 0.1ml

Anti-Phospho-NMDAR2A (Tyr1325) /FITC 荧光素标记磷酸化谷氨酸受体2A抗体IgGMulti-class antibodies规格： 0.2ml

Anti-CEA/HRP 辣根过氧化物酶标记鼠抗人癌胚抗原单克隆抗体(检测)IgGMulti-class antibodies规格： 0.2ml

CD167a抗体 Anti-CD167a/DDR1 0.1ml

Goat Anti-Mouse IgM/Gold 胶体金标记的羊抗小鼠IgM 0.5ml

FK506 binding protein associated protein 英文名称： FK506结合蛋白相关蛋白抗体(他克莫司相关蛋白) 0.2ml

Rhesus antibody Rh PMA/Prostate Mucin Antigen 粘蛋白抗原抗体 规格 0.2ml

Anti-CEA/HRP 辣根过氧化物酶标记鼠抗人癌胚抗原单克隆抗体(检测)IgGMulti-class antibodies规格： 0.2ml

Anti-IKI3 family protein/FITC 荧光素标记拟南芥IKI3抗体IgGMulti-class antibodies规格： 0.2ml

anti-pRb/p105-Rb /FITC 荧光素标记磷酸化成视网膜细胞瘤蛋白抗体IgGMulti-class antibodies规格： 0.1ml

Rhesus antibody Rh AQP0/MIP26 水通道蛋白0抗体 规格 0.1ml

Rabbit anti-MG IgG/Cy3 Cy3标记的兔抗长爪沙鼠IgG 0.1ml

GGNBP1 英文名称： 配子生成素结合蛋白1抗体 0.2ml

Rhesus antibody Rh Rabbit Anti-Mink IgG/Alexa Fluor 555 Alexa Fluor 555标记的兔抗水貂IgG 规格 0.1ml

anti-pRb/p105-Rb /FITC 荧光素标记磷酸化成视网膜细胞瘤蛋白抗体IgGMulti-class antibodies规格： 0.1ml

大鼠巨噬细胞炎性蛋白3α(MIP-3α/CCL20)ELISA试剂盒 ，英文名： MIP-3α/CCL20 ELISA Kit

人凋亡相关因子配体(FASL)ELISA检测试剂盒HumanFactor-relatedApoptosisligand,FASLELISAKit 96T/48T

病毒(CSFV)核酸检测试剂盒(PCR-荧光探针法) 48T

CLIAKitforNKAELISAKit(Ret)大鼠神经肽A规格：48T/96T

体液CMV(CYTOMEGALOVIRUS)病毒定量PCR扩增检测试剂盒20次

ELISAKitTCGF-Ⅲ人T细胞生长因子-Ⅲ规格：48T/96T

大鼠白介素1α(IL-1α)ELISA试剂盒 ，英文名： IL-1α ELISA Kit

Rabbit maix metalloproteinase 5 (MMP-5) ELISA Kit 兔子基质金属蛋白酶5(MMP-5)ELISA试剂盒

ELISA 小鼠白介素-17(mouse IL-17) 48T/96T 进口分装

CLIAKitforIL-3(HumanIerleukin3)ELISAKIT人白介素3规格：48T/96T

通用型鸡马立克氏病Marek’sdiseasevirus(MDV)试剂盒20次

ELISAKitypsin大鼠胰蛋白酶规格：48T/96T

Ⅱ型胶原α1 N端前体肽抗体费用 大鼠不对称二甲基精酸(ADMA)ELISA试剂盒 96T/48T 试剂盒 组装/原装

人免疫球蛋白E Fc段受体Ⅰ(FcεRⅠ)免疫试剂盒 Human Receptor Ⅰ for the Fc region of immunoglobulin E,FcεRⅠ ELISA Kit

MouseVascuoarendothelialcellgrowthfactorreceptor1,VEGFR-1/Flt1ELISAKit小鼠内皮细胞生长因子受体1(VEGFR-1/Flt1)ELISA试剂盒规格：96T/48T

石蜡切片组织CASPASE-3蛋白表达NBT显色光学显微镜检测试剂盒10/20次

humanProstaglandinF,PG-FELISA试剂盒人素F(PGF)ELISA试剂盒规格：96T/48T

HumahymosinELISAKit人胸腺肽(Thymosin)ELISA试剂盒规格：96T/48T

技术外包服务:

★Ⅱ型胶原α1 N端前体肽抗体费用 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。