中文名称  转录因子Pax6抗体费用 

英文名称  Anti-PAX6

别    名 AN 2; AN antibody; AN2; Aniridia type II protein; D11S812E; MGC17209; MGDA; Oculorhombin; Paired box 6; Paired box gene 6 (aniridia keratitis); Paired Box Gene 6; Paired box homeotic gene 6; Paired box protein Pax-6; Paired box protein Pax6; PAX 6; PAX6; PAX6_HUMAN; Sey; WAGR.

产品属性：

转录因子Pax6抗体费用 浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep

产品类型   一抗  

研究领域    发育生物学 神经生物学 干细胞

蛋白分子量  predicted molecular weight: 46kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PAX6(54-103 aa)

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

转录因子Pax6抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. The PAX2 gene is expressed in primitive cells of the kidney, ureter, eye, ear, and central nervous system. More specifically, in human embryo sections, PAX2 is expressed in the optic vesicle and later in the retina, in the otic vesicle and later in the semicircular canals of the inner ear, and in mesonephros, metanephros, adrenals, spinal cord, and hindbrain. PAX2 mutations can be responsible for renal hypoplasia, either isolated or associated with various ophthalmologic manifestations ranging from retinal coloboma to microphthalmia. The gene which encodes Pax-2 maps to human chromosome 10q24.3-q25.1. Lesions in the PAX6 gene accounts for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The gene which encodes Pax-6 maps to human chromosome 11p13.

Function : Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Subunit : Interacts with MAF and MAFB (By similarity). Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences.

Subcellular Location : Nucleus.

Post-translational modifications : Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.

DISEASE : Defects in PAX6 are the cause of aniridia (AN) [MIM:106210]. A congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time.

Defects in PAX6 are a cause of Peters anomaly (PAN) [MIM:604229]. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.

Defects in PAX6 are a cause of foveal hypoplasia (FOVHYP) [MIM:136520]. Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant.

Defects in PAX6 are a cause of keratitis hereditary (KERH) [MIM:148190]. An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization.

Defects in PAX6 are a cause of coloboma of iris choroid and retina (COI) [MIM:120200]; also known as uveoretinal coloboma. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Severe colobomatous malformations may cause as much as 10% of the childhood blindness. The clinical presentation of ocular coloboma is variable. Some individuals may present with minimal defects in the anterior iris leaf without other ocular defects. More complex malformations create a combination of iris, uveoretinal and/or optic nerve defects without or with microphthalmia or even anophthalmia.

Defects in PAX6 are a cause of coloboma of optic nerve (COLON) [MIM:120430].

Defects in PAX6 are a cause of bilateral optic nerve hypoplasia (BONH) [MIM:165550]; also known as bilateral optic nerve aplasia. A congenital anomaly in which the optic disc appears abnormally small. It may be an isolated finding or part of a spectrum of anatomic and functional abnormalities that includes partial or complete agenesis of the septum pellucidum, other midline brain defects, cerebral anomalies, pituitary dysfunction, and structural abnormalities of the pituitary.

Defects in PAX6 are a cause of aniridia cerebellar ataxia and mental deficiency (ACAMD) [MIM:206700]; also known as Gillespie syndrome. A rare condition consisting of partial rudimentary iris, cerebellar impairment of the ability to perform coordinated voluntary movements, and mental retardation.

Similarity : Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Contains 1 paired domain.

实验流程：

全、新、优、品、好四大特点：

转录因子Pax6抗体费用 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★转录因子Pax6抗体费用 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

Apo A1(Human anti-apolipoprotein A1 antibody) ELISA Kit 人抗载脂蛋白抗体A1Multi-class antibodies规格： 48T

Anti-phospho-IkB beta (Ser23) 磷酸化KB抑制蛋白β抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh MAGEB4 相关抗原B4抗体 规格 0.2ml

25(OH)D3/25 HVD3(Human 25-Dihydroxy vitamin D3)ELISA Kit 人25羟基维生素D3 96T

ROR alpha 英文名称： 维相关孤儿受体α抗体 0.2ml

CC85C 英文名称： 卷曲螺旋域蛋白质85C抗体 0.2ml

Anti-phospho-IkB beta (Ser23) 磷酸化KB抑制蛋白β抗体Multi-class antibodies规格： 0.1ml

BK(Mouse bradykinin) ELISA Kit 小鼠舒缓激肽Multi-class antibodies规格： 48T

Anti-CD79A/IGBP-1 /FITC 荧光素标记免疫球蛋白结合蛋白-1抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh DPF2/D4 zinc and double PHD fingers family 2 双PHD-D4锌指蛋白2抗体 规格 0.2ml

CMV 巨细胞病毒 IgG(间接法二步法)

MURF3 英文名称： 肌肉特异性环指蛋白3抗体 0.2ml

ALAD 英文名称： δ基乙酰脱水酶抗体 0.2ml

Anti-CD79A/IGBP-1 /FITC 荧光素标记免疫球蛋白结合蛋白-1抗体IgGMulti-class antibodies规格： 0.2ml

Anti-MTLR/FITC 荧光素标记抗胃动素受体抗体IgGMulti-class antibodies规格： 0.2ml

Anti-UCN/FITC 荧光素标记新型活性因子UCN抗体(小鼠、大鼠)IgGMulti-class antibodies规格： 0.2ml

拮抗凋亡转录因子抗体 Anti-AATF 0.2ml

Mouse Anti-rabbit IgG/FITC FITC标记的小鼠抗兔IgG 0.3ml

GCOM1 英文名称： GCOM1蛋白抗体 0.2ml

Rhesus antibody Rh PSA(Pa3) 人特异性抗原单克隆抗体(包被) 规格 0.1ml

Anti-UCN/FITC 荧光素标记新型活性因子UCN抗体(小鼠、大鼠)IgGMulti-class antibodies规格： 0.2ml

大鼠甲状腺素(T4)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人去乙酰化酶Siuin-2(SI2/SIR2L/SIR2L2)免疫试剂盒 Human SI2/SIR2L/SIR2L2 ELISA Kit

MouseL-SelectinELISAKit小鼠L选择素(L-Selectin/CD62L)ELISA试剂盒规格：96T/48T

IL-8(抗人;抗兔;抗小鼠;抗大鼠)100微克

Humanneuophilpeptide1-3,HNP1-3ELISA试剂盒人中性粒细胞防御素1-3(HNP1-3)ELISA试剂盒规格：96T/48T

HumanPulmonarysurfatca-associatedproteinA，SP-AELISAKit人肺表面活性物质相关蛋白A(SP-A)ELISA试剂盒规格：96T/48T

大鼠β-转导重复相容蛋白(β-CP)ELISA试剂盒 ，英文名： β-CP ELISA Kit

Mouse esadiol (E2) ELISA Kit 小鼠雌二醇(E2)ELISA试剂盒

ELISA 小鼠基质金属蛋白酶-9(mouse MMP-9) 48T/96T 进口分装

CLIAKitforIL-16(HumanIerleukin16)ELISAKIT人白介素16规格：48T/96T

通用型硫氰酸酶(rhodanase)活性比色法定量检测试剂盒20次

ELISAKitBK大鼠舒缓激肽规格：48T/96T

转录因子Pax6抗体费用 大鼠白细胞介素6(IL-6)ELISA试剂盒 ，英文名： IL-6 ELISA Kit

Mouse macrophage inflammatory protein 1 alpha (MIP-1 alpha /CCL3) ELISA Kit 小鼠巨噬细胞炎性蛋白1α(MIP-1α/CCL3)ELISA试剂盒

MouseorphaninFQ/nociceptin,OFQ/NELISAKit 小鼠孤腓肽(OFQ/N)ELISA试剂盒 96T/48T 进口分装

CLIAKitforHumanorosomucoid,ORMELISAKit人类粘蛋白规格：48T/96T

同位素核酸(酶切产物)蛋白结合DNA酶足迹法分析试剂盒10次

ELISAKitG-CSF大鼠粒细胞集落刺激因子规格：48T/96T