PDZ结构域蛋白GOPC抗体品牌 英文名称  Anti-PIST/GOPC

中文名称  PDZ结构域蛋白GOPC抗体品牌 

别    名 CAL; CFTR associated ligand; CFTR-associated ligand; FIG; Fused in glioblastoma; Golgi associated PDZ and coiled coil motif containing; Golgi associated PDZ and coiled coil motif containing protein; Golgi-associated PDZ and coiled-coil motif-containing protein; GOPC; GOPC_HUMAN; GOPC1; OTTHUMP00000040403; PDZ protein interacting specifically with TC 10; PDZ protein interacting specifically with TC10; PDZ/coiled coil domain binding partner for the rho family GTPase TC 10; PDZ/coiled coil domain binding partner for the rho family GTPase TC10; PIST; Protein interacting specifically with Tc 10; Protein interacting specifically with Tc10; dJ94G16.2; dJ94G16.2 PIST.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep

产品类型   一抗  

研究领域     细胞生物 信号转导

蛋白分子量  predicted molecular weight: 50kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PIST

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

PDZ结构域蛋白GOPC抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PIST (PDZ protein interacting specifically with TC10), also known as GOPC (golgi associated PDZ and coiled-coil motif containing), CAL or FIG, is a 462 amino acid protein that localizes to the cytoplasm, as well as to the membrane of the golgi apparatus and to the cell junction. Expressed ubiquitously and containing one PDZ (DHR) domain, PIST functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, PIST is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding PIST are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Three isoforms of PIST exist due to alternative splicing events.

Function : Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.

Subunit : Homooligomer. Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By similarity). Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ.

Subcellular Location : Cytoplasm. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.

DISEASE : Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.

Similarity : Contains 1 PDZ (DHR) domain.

Database links : UniProtKB/Swiss-Prot: Q9HD26.1

实验流程：

全、新、优、品、好四大特点：

PDZ结构域蛋白GOPC抗体品牌 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

AVP(Human arginine vasopressin) ELISA Kit 人精氨酸加压素Multi-class antibodies规格： 48T

Anti-KCNH1/EAG1 离子通道蛋白EAG1抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh MLL5 髓系/淋巴混合谱系蛋白5抗体 规格 0.2ml

SOD(Human Super Oxidase Dimutase) ELISA Kit 人超氧化物歧化酶 96T

RPA32 英文名称： 复制因子A蛋白2 0.2ml

C2orf61 英文名称： 2号染色体开放阅读框61抗体 0.2ml

Anti-KCNH1/EAG1 离子通道蛋白EAG1抗体Multi-class antibodies规格： 0.2ml

Runx3 一种新发现的基因(抗原)Multi-class antibodies规格： 0.5mg

Anti-CD72/Ly-32 CD72蛋白抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh p107/RBL1 视网膜母细胞瘤样蛋白p107抗体 规格 0.1ml

CSF2 Kit Human 人 GM-CSF / CSF2 ELISA配对抗体 ELISA

THEMIS 英文名称： 选择性胸腺细胞相关蛋白抗体 0.2ml

CHCHD5 英文名称： 卷曲螺旋结构域蛋白CHCHD5抗体 0.2ml

Anti-CD72/Ly-32 CD72蛋白抗体Multi-class antibodies规格： 0.2ml

Anti-HERG/FITC 荧光素标记特异性离子通道蛋白抗体IgGMulti-class antibodies规格： 0.2ml

Anti-PHB/FITC 荧光素标记抑制素/抑制因子抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh AVEN 细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂) 规格 0.1ml

ShK(Stichodactyla helianthus Neurotoxin)-(Arg22) 海葵神经毒素(35肽) 0.1mg

GCNF 英文名称： 细胞核因子GCNF/维受体相关受体抗体 0.2ml

Rhesus antibody Rh Rabbit anti-mouse Kappa light chain/PE PE标记的兔抗小鼠k链 规格 0.1ml

Anti-PHB/FITC 荧光素标记抑制素/抑制因子抗体IgGMulti-class antibodies规格： 0.2ml

大鼠甲状旁腺激素相关蛋白(PTHrP) ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人去唾液酸糖蛋白受体(ASGPR)抗体免疫试剂盒 Human asialoglyco protein receptor(ASGPR)aibody ELISA Kit

MouselymphocytefactorELISAKit小鼠淋巴细胞因子ELISA试剂盒规格：96T/48T

INSULI-ALPHA蛋白表达西方杂交分析试剂盒5次

Humanniicoxide,NOELISA试剂盒人(NO)ELISA试剂盒规格：96T/48T

HumanPulmonarysurfatca-associatedproteinD,SP-DELISAKit人肺表面活性物质相关蛋白D(SP-D)ELISA试剂盒规格：96T/48T

大鼠β细胞素(BTC)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人磷脂酰肌醇抗体(IgM)免疫试剂盒 Human phosphatidylinositol aibody IgM ELISA Kit

PorcineB-cellleukemia/lymphoma2,Bcl-2ELISAKit猪B细胞因子2(Bcl-2)ELISA试剂盒规格：96T/48T

石蜡切片组织线粒体复合物III蛋白表达NBT显色光学显微镜检测试剂盒10/20次

Humaetinolbindingprotein4,RBP-4ELISA试剂盒人视黄醇结合蛋白4(RBP-4)ELISA试剂盒规格：96T/48T

Humaumor-associatedaigen,TAAELISAKit人相关抗原(TAA)ELISA试剂盒规格：96T/48T

PDZ结构域蛋白GOPC抗体品牌 大鼠白细胞介素1β(IL-1B)ELISA试剂盒 ，英文名： IL-1B ELISA Kit

Mouse macrophage inflammatory protein 3 beta (MIP-3 beta /ELC/CCL19) ELISA Kit 小鼠巨噬细胞炎性蛋白3β(MIP-3β/ELC/CCL19)ELISA试剂盒

MouseBromodeoxyuridine,BrdUELISAKit 小鼠溴脱氧核苷尿嘧啶(BrdU)ELISA试剂盒 96T/48T 进口分装

CLIAKitforHumanomeinELISAKit人网膜素规格：48T/96T

同位素核酸-蛋白结合凝胶电泳定量分析(McKay)试剂盒20次

ELISAKitsVCAM-1大鼠可溶性细胞粘附分子1规格：48T/96T

技术外包服务:

★PDZ结构域蛋白GOPC抗体品牌 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。