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颗粒蛋白前体抗体说明书 英文名称  Anti-PGRN/Granulin

中文名称  颗粒蛋白前体抗体说明书 

别    名 Granulin; Acrogranin; GEP; GP88; Granulin epithelin; GRN; PC cell derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G

产品类型   一抗  

研究领域     免疫学 神经生物学 信号转导

蛋白分子量  predicted molecular weight: 63kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PGNR C-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

颗粒蛋白前体抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Function : Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.

Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

Subcellular Location : Secreted.

Post-translational modifications : Granulins are disulfide bridged.

DISEASE : Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.

Similarity : Belongs to the granulin family.

1.PGRN目前主要。是65岁以下人群中第二种最常见的形式，该蛋白的多量产生，能够损坏记忆和个性，而且还可能影响运动。这一发现也许可帮助解决关于该疾病病因的困惑： 症(FTD)是常见的疾病，可见，除微管相关的tau蛋白导致症外，又一个新的与症有关蛋白又被科学家发现。

2.颗粒蛋白前体（PGRN）在。PGRN能过度增殖、以及促进组织新生，提示它可能是的一个非常重要的靶标。

实验流程：

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