全、新、优、品、好四大特点：

蛋白酪氨酸磷酸酶-1B抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

蛋白酪氨酸磷酸酶-1B抗体规格 英文名称  Anti-PTP1B

中文名称  蛋白酪氨酸磷酸酶-1B抗体规格 

别    名 PTP-1B; Non receptor tyrosine phosphatase 1; Protein tyrosine phosphatase 1B; Protein-tyrosine phosphatase 1B; Protein tyrosine phosphatase non receptor type 1; Protein tyrosine phosphatase placental; PTP 1B; PTPN 1; PTPN1; Tyrosine protein phosphatase non receptor type 1; PTP-HA2; Protein-tyrosine phosphatase HA2.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Pig, Cow, Horse, Rabbit

产品类型   一抗  

研究领域    细胞生物 神经生物学 信号转导 激酶和磷酸酶

蛋白分子量  predicted molecular weight: 48kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PTP-1B C-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

蛋白酪氨酸磷酸酶-1B抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and is a drug discovery target in the fields of diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B.

PTP1B also interacts with Insulin and EGF receptors, and undergoes phosphorylation after receptor stimulation. Tyrosine phosphorylation at Tyr-66, Tyr-152, and Tyr-153 occurs after insulin receptor activation, and tyrosine phosphorylation of Tyr-152 may be required for interactions with N-Cadherin. In addition, Akt can phosphorylate Ser-50 and this phosphorylation can reduce PTP1B activity.

Function : Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion

Subunit : Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function.

Tissue Specificity : Most abundant in testis. Also found in kidney, spleen, muscle, liver, heart and brain.

Post-translational modifications : Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.

S-nitrosylation of Cys-215 inactivates the enzyme activity.

Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.

蛋白酪氨酸磷酸酶1B（PTP1B）是一种信号的负性调节因子，与和的及发展关系密切。对P-tyr基因敲除小鼠的研究表明，缺失PTP1B小鼠的敏感性明显增加，并对有一定的抵抗作用，而另一些对动物和人体的研究结果却与此相反，发现PTP1B可通过引起抵抗、瘦素抵抗及影响脂代谢等而导致和的发生。一些特异性的Ptyr小分子抑制剂已经开发并用于和的中。

实验流程：

正在热销的相关产品：

Anti-BAFF/CD257/FITC 荧光素标记TNF家族B细胞激活因子抗体IgGMulti-class antibodies规格： 0.2ml

Anti-phospho-Arhgef2 (Ser810)/FITC 荧光素标记抗人、大、小鼠磷酸化Rho鸟苷酸交换因子2抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh CLASP2 细胞连接相关蛋白2抗体 规格 0.2ml

HHV8/ORF K2/vIL-6(Human herpesvirus 8) 人类病毒8抗原 0.5mg

IDE 英文名称： 降解酶抗体 0.2ml

Rhesus antibody Rh TRF2 端粒结合蛋白2抗体 规格 0.1ml

Anti-phospho-Arhgef2 (Ser810)/FITC 荧光素标记抗人、大、小鼠磷酸化Rho鸟苷酸交换因子2抗体IgGMulti-class antibodies规格： 0.2ml

Anti-p-Klf5/CKLF /FITC 荧光素标记磷酸化肠道内富含的Kruppel样因子5抗体IgGMulti-class antibodies规格： 0.2ml

Anti-Phospho-SHIP2 (Tyr542)/FITC 荧光素标记磷酸化蛋白酪氨酸磷酸酶2抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh AMBP/Alpha 1 microglobulin α1微球蛋白抗体 规格 0.2ml

Rabbit Anti-human sIgA/Alexa Fluor 350 Alexa Fluor 350标记的兔抗人分泌型IgA 0.1ml

GNB1L 英文名称： G蛋白β样蛋白抗体 0.2ml

Rhesus antibody Rh Rabbit anti-horse IgG whole serum 兔抗马IgG抗血清 规格 1ml

Anti-Phospho-SHIP2 (Tyr542)/FITC 荧光素标记磷酸化蛋白酪氨酸磷酸酶2抗体IgGMulti-class antibodies规格： 0.2ml

AZU(Human azurocidin) ELISA Kit 人天青杀素Multi-class antibodies规格： 48T

Anti-NeuroD1 神经元分化因子1抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh IL-20R alpha/IL20RA 白介素20受体α链抗体 规格 0.2ml

sP-selectin(Mouse soluble P-selectin) ELISA Kit 小鼠可溶性P选择素 96T

Phospho-p40phox (Thr154) 英文名称： 磷酸化嗜中性粒细胞胞浆因子4抗体 0.1ml

CD38 英文名称： CD38抗体 0.1ml

Anti-NeuroD1 神经元分化因子1抗体Multi-class antibodies规格： 0.2ml

CL-0160Molt-4(人急性淋巴母细胞细胞)5×106cells/瓶×2

HA Others H1N1 甲型 H1N1 (A/California/04/2009) 血凝素 (Hemagglutinin / HA) 杆状病毒-昆虫细胞裂解液 (阳性对照)

人主动脉平滑肌细胞裂解物HASMCL

SK-HEP-1细胞，人细胞 人低转移细胞,95-C细胞 脑动脉内皮细胞Many types of cells包装：5 × 105次方(1ml)

兔主动脉平滑肌细胞;CCC-SMC-1

TIMP1 Others Human 人 TIMP-1 / TIMP1 人细胞裂解液 (阳性对照)

CL-0159MLTC-1(小鼠间质细胞瘤细胞)5×106cells/瓶×2

ASGR1 Others Human 人 ASGPR1 / ASGR1 人细胞裂解液 (阳性对照)

小鼠肝实质细胞完全培养基 100mL

CT26.WT小鼠细胞 CT26.WT mouse colon cancer cells DMEM培养基+10%FBS

LIF Protein Human 重组人 LIF 蛋白 (His 标签)

RKO-AS45-1(人转基因细胞) 5×106cells/瓶×2 6T-CEM(T细胞)

蛋白酪氨酸磷酸酶-1B抗体规格 KIR2DL4 Others Human 人 KIR2DL4 / CD158D CHO细胞裂解液 (阳性对照)

CL-0106HFL1(人)5×106cells/瓶×2

人表皮黑色素细胞-浅色素裂解物HELM-l L

新生牛眼晶体上皮细胞;NBLE 人细胞，SW579细胞 RIN-m5F细胞，小鼠β瘤细胞

人膀胱上皮永生化细胞;SV-HUC-1

EPHA4 Others Human 人 EPHA4 人细胞裂解液 (阳性对照)

技术外包服务:

★蛋白酪氨酸磷酸酶-1B抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。