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维甲酸相关孤儿受体α抗体品牌 英文名称  Anti-ROR1/ROR alpha

中文名称  维甲酸相关孤儿受体α抗体品牌 

别    名 NR1F1; Nuclear receptor ROR alpha; Nuclear receptor RZR alpha; RAR related orphan receptor A; RAR related orphan receptor alpha; ROR 1; ROR 2; ROR 3; ROR A; ROR1; ROR2.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型   一抗  

研究领域     细胞生物 染色质和核信号 神经生物学 细胞周期蛋白 细胞分化

蛋白分子量  predicted molecular weight: 100kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human ROR1/ROR alpha corresponding to amino acids 365-406.

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

维甲酸相关孤儿受体α抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 NR1F1; Retinoid related orphan receptor alpha (ROR alpha) is a NR1 Thyroid Hormone Like Receptor. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Within the ROR alpha group there are ROR alpha 1, 2, 3, and 4. These isotypes have been shown to differ in only their amino terminus, and their spatiotemporal expression appears to be under isoform specific regulation. ROR alpha isoforms have the same DNA binding domain but display different DNA binding specificities. ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity and displays weaker transcriptional activity. The structure of the ligand binding domain (LBD) of ROR alpha and a potential natural ligand have been elucidated. ROR alpha expression has been documented in human adipose, brain, breast, heart, liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen and testis. Research has shown that these proteins are key factors in the regulation of many physiological processes such as cell growth and differentiation. ROR alpha is also critical for proper cerebellar development, modulation of gene expression in response to hypoxic stress, and migratory capacities of cancer cells.

Function : Tyrosine-protein kinase receptor whose role is not yet clear.

Subcellular Location : Membrane; Single-pass type I membrane protein.

Tissue Specificity : Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Contains 1 FZ (frizzled) domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 kringle domain.

Contains 1 protein kinase domain.

Database links : UniProtKB/Swiss-Prot: Q01973.2

实验流程：

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