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尿酸盐重吸收转运子1抗体规格 英文名称  Anti-URAT1/SLC22A11

中文名称  尿酸盐重吸收转运子1抗体规格 

别    名 SLC22A11; S22AC_HUMAN; OAT4L; Solute carrier family 22 member 12; Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1; Urate 1 transporter protein; solute carrier family 22 (organic anion/cation transporter), member12; slc22a12.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg 1ml/1mg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Mouse, Rat

产品类型   一抗  

研究领域    转运蛋白

蛋白分子量  predicted molecular weight: 61kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from mouse SLC22A11

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

尿酸盐重吸收转运子1抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 URAT1 Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC. These families play critical roles in the transepithelial transport of organic anions in the kidneys as well as in other tissues such as the liver and brain. Among these families, the OAT family plays the central role in renal organic anion transport. Knowledge of these three families at the molecular level, such as substrate selectivity, tissue distribution, and gene localization, is rapidly increasing.

Function : Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.

Subunit : Interacts with PDZK1.

Subcellular Location : Cell membrane; Multi-pass membrane protein. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules.

Tissue Specificity : Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.

DISEASE : Hypouricemia renal 1 (RHUC1) [MIM:220150]: A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity : Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Database links : UniProtKB/Swiss-Prot: Q96S37.1

尿酸盐重吸收转蛋白-1又称：OAT4L(organic anion transporter 4-like)（URAT-1由SLC22A12编码），是一种尿酸-阴离子交换蛋白，调节着血液尿酸水平，是尿酸促排与抗尿酸排泄药物的作用靶位。鼠URAT1与人有74%同源性。

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